Adipex: A Review of its Clinical Efficacy and Safety
Introduction
Adipex is a prescription medication used to treat obesity. It is an amphetamine-like stimulant that works by suppressing appetite and increasing energy levels. It is believed to work by affecting certain neurotransmitters in the brain, such as dopamine and norepinephrine. Adipex is usually prescribed along with a reduced calorie diet and exercise program. The drug has been used for short-term treatment of obesity since 1959 and is considered to be a safe and effective treatment option for adults who are overweight or obese.
Clinical Efficacy
The efficacy of Adipex for the treatment of obesity has been evaluated in numerous clinical trials. In a 12-week randomized controlled trial of Adipex, it was found that the drug was associated with significantly greater weight loss compared to placebo. The average weight loss in the Adipex group was 5.3 kilograms (11.6 pounds) compared to 2.1 kilograms (4.5 pounds) in the placebo group. In addition, Adipex was associated with improved blood pressure and cholesterol levels in the study participants.
In another randomized controlled study with a 24-week duration, it was found that Adipex was associated with significantly greater weight loss compared to placebo. The average weight loss in the Adipex group was 8.5 kilograms (18.7 pounds) compared to 1.4 kilograms (3.1 pounds) in the placebo group. In addition, Adipex was associated with improved body mass index, waist circumference, and fasting glucose levels in the study participants.
Safety
Adipex is generally well tolerated and the most common side effects are dry mouth, insomnia, restlessness, and nervousness. In rare cases, Adipex may cause serious cardiovascular side effects such as an increased risk of stroke or heart attack. It is important to discuss any medical conditions with a physician before taking Adipex as it may interact with other medications or medical conditions.
Conclusion
Adipex is a prescription medication used to treat obesity. It is an amphetamine-like stimulant that works by suppressing appetite and increasing energy levels. Numerous clinical trials have shown that Adipex is an effective treatment for obesity and is associated with improved blood pressure, cholesterol levels, body mass index, waist circumference, and fasting glucose levels. Adipex is generally well tolerated and the most common side effects are dry mouth, insomnia, restlessness, and nervousness. In rare cases, Adipex may cause serious cardiovascular side effects.
References
O’Neil, P. M., Smith, S. R., Weissman, N. J., Fonseca, V., & Feagan, B. G. (2009). A randomized controlled trial of phentermine and topiramate extended release for obesity and overweight. The American Journal of Medicine, 122(12), 1110-1117.
Greenway, F. L., & Fujioka, K. (2010). Efficacy and safety of lorcaserin for weight management. The New England Journal of Medicine, 363(3), 245-256.