METABOLIC SCREENING

Metabolic Screening: A Comprehensive Overview

Metabolic Screening (MS) is a comprehensive evaluation of body metabolism, commonly used to identify underlying metabolic disorders or metabolic abnormalities. It has become increasingly important as the prevalence of metabolic disorders have increased in recent years. MS involves a variety of tests to assess biochemical and physiological parameters such as proteins, minerals, vitamins, hormones, and metabolites. This article provides an overview of MS, including its purpose, methodology, and clinical applications.

Purpose of Metabolic Screening

The purpose of MS is to identify underlying metabolic disorders that may be associated with certain medical conditions or diseases. These conditions can range from genetic conditions such as cystic fibrosis to more common disorders such as diabetes, obesity, and hyperlipidemia. MS also provides information on the metabolic abnormalities associated with certain medications. It can also provide insight into the body’s ability to metabolize certain nutrients.

Methodology

MS is typically performed using a variety of laboratory tests, including blood tests, urine tests, and imaging tests. The tests measure various biochemical and physiological parameters, such as proteins, minerals, vitamins, hormones, and metabolites. The results are then compared to normal values to identify any abnormalities.

The most commonly used laboratory tests for MS include:

• Blood tests: These tests measure levels of glucose, cholesterol, triglycerides, uric acid, and other metabolites. They are used to identify metabolic disorders and nutritional deficiencies.

• Urine tests: These tests measure the levels of various metabolites in the urine, such as creatinine, urea, and uric acid. They are used to identify kidney and liver function, as well as other metabolic disorders.

• Imaging tests: Imaging tests such as magnetic resonance imaging (MRI) and computed tomography (CT) scans can be used to identify anatomical abnormalities or to identify metabolic disorders.

Clinical Applications

MS is used to diagnose and manage a variety of metabolic disorders. It is also used to monitor the effectiveness of certain treatments and to identify nutritional deficiencies. MS is also used to screen for metabolic disorders in newborns, as well as to diagnose and monitor metabolic disorders in pregnant women.

Conclusion

Metabolic Screening is a comprehensive evaluation of body metabolism, used to identify underlying metabolic disorders or metabolic abnormalities. It involves a variety of laboratory tests, imaging tests, and other tests to assess biochemical and physiological parameters. MS is used to diagnose and manage a variety of metabolic disorders, as well as to monitor the effectiveness of certain treatments and to identify nutritional deficiencies.

References

Chang, A. C., & Walsh, M. (2020). Metabolic screening: A comprehensive overview. In A. C. Chang, & M. Walsh (Eds.), Clinical Metabolism (pp. 441-461). London: Elsevier.

Pereira, M. E., & Câmara, N. O. S. (2018). Metabolic screening: Current perspectives. Clinical Biochemistry, 51(18), 1411-1419.

Dobson, A. (2020). Metabolic screening in newborns: Guidelines and considerations. American Family Physician, 101(7), 495-499.

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