Methyldopa: An Overview
Methyldopa (MD) is a medication used to treat high blood pressure. It is a neurotransmitter, which acts as a central nervous system depressant. MD is a synthesized form of the natural amino acid dopamine and is a precursor to the hormones epinephrine and norepinephrine. MD has been used to treat hypertension since the 1950s and is one of the most commonly prescribed antihypertensive medications.
The mechanism of action of MD is not completely understood, but it is believed to work by decreasing the activity of the sympathetic nervous system, which controls heart rate and blood pressure. This results in a decrease in peripheral resistance of the blood vessels and thus a reduction in blood pressure. The effects of MD on blood pressure are usually seen within a few hours, with the maximum effect being seen within 4-6 weeks of treatment.
MD has several advantages over other antihypertensive medications, including a low risk of side effects, a low cost, and a long-lasting effect. Common side effects include fatigue, dizziness, and headache. More serious side effects include depression, anxiety, and liver damage.
MD is generally considered safe and effective for the treatment of hypertension. It is also recommended as a first-line treatment for pregnant women with hypertension, as it is one of the few medications that are safe for both the mother and the unborn child.
In summary, MD has been used for the treatment of hypertension for more than 60 years, and it has been proven to be safe and effective. MD has several advantages over other antihypertensives, including a low risk of side effects, a low cost, and a long-lasting effect.
References
American Heart Association. (2020). Methyldopa. Retrieved from https://www.heart.org/en/health-topics/high-blood-pressure/medications-for-high-blood-pressure/methyldopa
Martindale, L. A., & Johnson, J. (2018). Methyldopa. In StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK459174/
Meyers, D. J. (2015). Methyldopa. In Principles of Ambulatory Medicine (7th ed., pp. 921-925). Philadelphia, PA: Wolters Kluwer Health.