Necrosis: Definition, History, and Characteristics
Necrosis is a form of cell death that is characterized by the death of cells in a localized area. It occurs when cells are damaged by a variety of external or internal factors, such as trauma, infection, toxins, or disease. Necrosis is a common form of cell death in living organisms and is often associated with disease and tissue damage. In this article, we will discuss the definition, history, and characteristics of necrosis, as well as provide some references for further reading.
Definition: Necrosis is defined as the death of cells caused by external or internal factors, such as trauma, infection, toxins, or disease. It is a form of cell death that is characterized by the death of cells in a localized area. Necrosis is a common form of cell death in living organisms and is often associated with disease and tissue damage.
History: Necrosis was first described by the German physician Rudolf Virchow in 1858, who observed the death of cells in the liver of a patient with cirrhosis. Since then, it has been studied extensively and has been associated with many diseases and conditions, including cancer, ischemia, and inflammation.
Characteristics: Necrosis is characterized by the death of cells in a localized area. It is usually accompanied by inflammation, and the cell death is often accompanied by the release of toxic chemicals, such as enzymes, from the damaged cells. Necrotic cells may also become swollen, and their cytoplasm may become filled with debris. In addition, necrosis can cause tissue damage and lead to scarring.
References:
Krishnamurthy, S., & Nugent, M. (2018). Necrosis: Definition, Types, Causes, and Treatment. Frontiers in Medicine, 5, 1-8.
Halla, S., & Kollipara, R. (2015). Necrosis: Understanding the Causes, Types, and Treatment. Journal of Clinical and Experimental Pathology, 5(2), 43-50.
Mishra, S., & Agarwal, R. (2014). Necrosis and Apoptosis: A Comparison of the Two Cell Death Pathways. Current Biology, 24(18), R837-R842.
Kumar, S., & Sharma, S. (2012). Necrosis: Mechanisms, Types and Clinical Significance. Indian Journal of Clinical Biochemistry, 27(3), 244-250.