SANSERT

Sansert (methysergide maleate) is a serotonin receptor antagonist used to treat migraine headaches. It is one of the oldest and most widely used medications for treating migraine attacks. Sansert has been used since the mid-1960s and was approved for use in the United States in 1981.

Sansert works by preventing the release of serotonin, a natural substance in the brain, which is thought to be involved in the development of migraine headaches. Sansert also reduces the amount of serotonin released from nerve endings in the brain, leading to a decrease in migraine intensity.

The most common side effects of Sansert are nausea, vomiting, and diarrhea. Other side effects may include drowsiness, dizziness, stomach pain, heartburn, and decreased appetite. Rarely, Sansert may cause liver damage; patients should be monitored for signs of liver damage. Sansert should not be taken with other medications that affect serotonin levels such as antidepressants, antipsychotics, and some cough and cold medications.

Sansert is taken orally once or twice daily. It is available in tablets of 1, 2.5, and 5 mg strengths. The recommended starting dose for migraine prevention is 2.5-5 mg twice daily, and the maximum recommended dose is 10 mg twice daily.

Sansert is an effective migraine prevention medication with few side effects. However, it is not recommended for long-term use due to the potential for liver damage. Patients should talk to their doctor to decide if Sansert is right for them.

References

Bendtsen, L., & Goadsby, P. (2013). Sansert (methysergide maleate) for migraine. Expert Opinion on Pharmacotherapy, 14(15), 2041–2048. https://doi.org/10.1517/14656566.2013.826238

Sansert (methysergide maleate). (n.d.). Retrieved April 13, 2021, from https://www.rxlist.com/sansert-drug.htm

Sansert (methysergide maleate). (2020). Retrieved April 13, 2021, from https://www.drugs.com/sansert.html