Tag: α-MSH

July 24, 2026 / Mohammed looti

POMC: The Biological Blueprint of Appetite and Mood

The role of the Proopiomelanocortin (POMC) system in the regulation of energy balance has been the subject of extensive research for several decades. POMC is a precursor peptide produced in the anterior pituitary gland that is cleaved into several peptides including β-endorphin, ACTH, and α-MSH. These peptides have well-documented roles in the regulation of food […]

July 22, 2026 / Mohammed looti

MC4-R: The Biological Key to Appetite Control

MELANOCORTIN-4 RECEPTOR (MC4-R): A Comprehensive Review Introduction to the Melanocortin System The Melanocortin-4 Receptor (MC4-R) is recognized as a pivotal G-protein coupled receptor (GPCR) within the central nervous system, serving as the master regulator of energy homeostasis, food intake, and body weight. Primarily expressed in key hypothalamic nuclei, MC4-R integrates diverse metabolic signals originating from […]