PRESENILIN
Introduction to Presenilins and Their Genetic Significance The term presenilin refers to a family of related multi-pass transmembrane proteins that function as the catalytic core of the gamma-secretase intramembrane protease complex. Discovered in the mid-1990s through genetic linkage studies of families afflicted by Early-Onset Familial Alzheimer’s Disease (EOFAD), presenilins have become central to our understanding […]