Tag: excitotoxicity

April 9, 2026 / Mohammed looti

EXCITOTOXICITY

Defining Excitotoxicity and Its Clinical Significance Excitotoxicity represents a complex and highly destructive pathological process wherein nerve cells suffer damage or total destruction due to excessive stimulation by neurotransmitters. In the context of the central and peripheral nervous systems, glutamate serves as the primary excitatory neurotransmitter, yet its dysregulation can lead to catastrophic cellular outcomes. […]

December 24, 2025 / Mohammed looti

EXCITOTOXIC LESION

Introduction to Excitotoxicity and Lesion Models Excitotoxicity is a critical concept in neurobiology, defining a pathological process wherein the excessive stimulation of neurons by excitatory neurotransmitters, principally glutamate, leads directly to neuronal damage, degeneration, and ultimately, cell death. This pathological cascade is not merely a theoretical mechanism but is deeply implicated in the acute and […]