Tag: glutamate receptors

December 25, 2025 / Mohammed looti

IONOTROPIC RECEPTOR

Ionotropic Receptors: An Overview of Structure and Function Ionotropic receptors (IRs) constitute a crucial superfamily of integral membrane proteins that are fundamentally responsible for mediating the vast majority of rapid synaptic transmission within the nervous system. Functioning as specialized ligand-gated ion channels, these receptors convert the binding of a specific neurotransmitter, or ligand, into an […]

December 24, 2025 / Mohammed looti

EXCITOTOXIC LESION

Introduction to Excitotoxicity and Lesion Models Excitotoxicity is a critical concept in neurobiology, defining a pathological process wherein the excessive stimulation of neurons by excitatory neurotransmitters, principally glutamate, leads directly to neuronal damage, degeneration, and ultimately, cell death. This pathological cascade is not merely a theoretical mechanism but is deeply implicated in the acute and […]