Tag: Hyperammonemia

November 3, 2025 / Mohammed looti

ARGININOSUCCINIC ACIDURIA

Introduction and Definition Argininosuccinic aciduria (ASA), also known as argininosuccinic acid lyase (ASL) deficiency, stands as one of the most prevalent inherited disorders affecting the urea cycle, a crucial metabolic pathway responsible for detoxifying ammonia in the body. This autosomal recessive condition is fundamentally characterized by the accumulation of **argininosuccinic acid** (ASA) within the systemic […]

September 28, 2025 / Mohammed looti

METABOLIC ENCEPHALOPATHY

Metabolic Encephalopathy Introduction to Metabolic Encephalopathy Metabolic encephalopathy is a complex and potentially severe neurological disorder that arises from a fundamental abnormality in the body’s metabolism. This condition is characterized by a significant decline in overall neurological functioning, manifesting through a broad spectrum of symptoms that can range from subtle cognitive deficits to profound alterations […]