Tag: melanocortin receptor

June 28, 2026 / Mohammed looti

Alpha-MSH: The Neurochemical Key to Mood Regulation

ALPHA-MELANOCYTE STIMULATING HORMONE (A-MSH) Alpha-Melanocyte Stimulating Hormone (A-MSH) is a critical neuroregulatory peptide belonging to the melanocortin family, derived through the intricate post-translational cleavage of the larger prohormone, Pro-opiomelanocortin (POMC). This highly potent tridecapeptide serves as a key signaling molecule within the central nervous system, where it acts as a non-selective agonist primarily targeting specific […]

Read More
January 28, 2026 / Mohammed looti

MELANOCORTIN-4 RECEPTOR (MC4-R)

MELANOCORTIN-4 RECEPTOR (MC4-R): A Comprehensive Review Introduction to the Melanocortin System The Melanocortin-4 Receptor (MC4-R) is recognized as a pivotal G-protein coupled receptor (GPCR) within the central nervous system, serving as the master regulator of energy homeostasis, food intake, and body weight. Primarily expressed in key hypothalamic nuclei, MC4-R integrates diverse metabolic signals originating from […]

Read More