Tag: neuron physiology

January 9, 2026 / Mohammed looti

LOCAL EXCITATORY STATE (LES)

Introduction to the Local Excitatory State (LES) The Local Excitatory State (LES) represents a fundamental concept in neurophysiology, describing a localized, temporary, yet sustained elevation in the intrinsic excitability of specific neuronal populations within the central nervous system. This phenomenon moves beyond simple transient synaptic transmission, suggesting a robust alteration in the neuron’s readiness to […]

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November 24, 2025 / Mohammed looti

DENDRITIC POTENTIAL

Introduction and Definition of Dendritic Potential The concept of the dendritic potential refers fundamentally to the stable, transmembrane voltage difference maintained across the plasma membrane of a neuron’s dendrite when the cell is in a quiescent or non-firing state. This potential, often measured relative to the extracellular fluid, is a crucial determinant of neuronal excitability […]

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