Tag: neuronal degeneration

May 24, 2026 / Mohammed looti

TRANSSYNAPTIC DEGENERATION

Introduction to Transsynaptic Degeneration Transsynaptic degeneration represents a complex and critically important pathological process within the central and peripheral nervous systems, wherein the primary damage or death of one neuron precipitates the subsequent degeneration and eventual demise of neurons that are synaptically connected to it. This phenomenon profoundly illustrates the intricate and interdependent nature of […]

December 24, 2025 / Mohammed looti

EXCITOTOXIC LESION

Introduction to Excitotoxicity and Lesion Models Excitotoxicity is a critical concept in neurobiology, defining a pathological process wherein the excessive stimulation of neurons by excitatory neurotransmitters, principally glutamate, leads directly to neuronal damage, degeneration, and ultimately, cell death. This pathological cascade is not merely a theoretical mechanism but is deeply implicated in the acute and […]