Tag: Pain transmission

May 16, 2026 / Mohammed looti

C FIBER

The Fundamental Nature of C Fibers: Structural and Physiological Foundations C fibers represent a distinct and vital class of unmyelinated afferent nerve fibers within the peripheral nervous system, serving as the primary conduits for a wide variety of sensory modalities. Unlike their myelinated counterparts, such as the A-delta and A-beta fibers, C fibers are characterized […]

November 13, 2025 / Mohammed looti

SPINAL GATE

Introduction to the Spinal Gate Mechanism The concept of the Spinal Gate, frequently referenced as the gating mechanism, is foundational to understanding the neurophysiology of pain perception and modulation within the central nervous system. This mechanism is an active, regulatory filter situated strategically within the dorsal horn of the spinal cord, primarily involving the intricate […]