Anticholinergic Drugs: Their Use in Clinical Practice
Anticholinergic drugs are medications that block the action of the neurotransmitter acetylcholine. This class of drugs includes a variety of agents that can be used to treat a wide range of medical conditions. This article will discuss the mechanisms of action, clinical indications, and common side effects of anticholinergic drugs.
The primary mechanism of action of anticholinergic drugs is to block the action of acetylcholine, which is an important neurotransmitter in the nervous system. Acetylcholine is involved in a variety of physiological functions, including muscle contraction, heart rate, and reflexes. By blocking the action of acetylcholine, anticholinergics can alter the activity of certain neurons, resulting in a variety of effects.
The most common clinical indication for anticholinergic drugs is the treatment of spasticity. These medications are commonly used to reduce spasticity in patients with a variety of neurological disorders, such as multiple sclerosis, cerebral palsy, and spinal cord injury. Anticholinergics can also be used to treat conditions such as urinary incontinence, overactive bladder, and certain types of gastrointestinal disorders.
Common side effects of anticholinergic drugs include dry mouth, blurred vision, constipation, and drowsiness. These side effects may be more pronounced in elderly patients and those with underlying medical conditions. In addition, patients should be monitored for any signs of an allergic reaction, such as rash, hives, or swelling.
In conclusion, anticholinergic drugs are a class of medications that can be used to treat a variety of medical conditions. These drugs act by blocking the action of acetylcholine, resulting in a variety of effects. Common clinical indications include the treatment of spasticity and urinary incontinence. Common side effects include dry mouth, blurred vision, constipation, and drowsiness. Patients should be monitored for any signs of an allergic reaction.
Abed, A. S., & Mardini, F. E. (2017). Anticholinergic drugs: A review of adverse effects and drug interactions. Clinical and Experimental Pharmacology and Physiology, 44(5), 497-504.
Chapple, C. R., & Milroy, E. J. (2015). Anticholinergic drugs for overactive bladder syndrome in adults. Cochrane Database of Systematic Reviews, 2015(7).
Cleveland Clinic (2020). Anticholinergics. Retrieved from https://my.clevelandclinic.org/health/drugs/17954-anticholinergics
Mayo Clinic (2020). Drugs and Supplements: Anticholinergic Drugs. Retrieved from https://www.mayoclinic.org/drugs-supplements/anticholinergic-drugs/safety/hrb-20059810