BASKET CELL

Basket Cells: Anatomy, Physiology, and Behavioral Implications

Abstract

The basket cell is a type of GABAergic interneuron found in the neocortex and hippocampus. This cell type is characterized by a high degree of morphological complexity, a distinct electrophysiological profile, and a wide variety of roles in cortical networks. In this review article, we discuss the anatomy, physiology, and behavioral implications of basket cells. We also provide an overview of the current literature on basket cells and suggest areas of future research.

Introduction

The basket cell has been studied extensively in the cortex and hippocampus and is one of the most commonly encountered interneurons. It is characterized by its complex dendritic tree, which is often highly branched and can span up to three layers of the cortex. Basket cells show a distinct electrophysiological profile, with a low threshold for spiking and a high degree of adaptation. This cell type plays a fundamental role in regulating the excitability of cortical networks and has been implicated in a wide variety of behaviors.

Anatomy

Basket cells are found in both the neocortex and hippocampus, though they are more numerous in the latter. These cells can span up to three layers of the cortex and have a complex dendritic tree, often with multiple secondary and tertiary branches. They are typically small to medium-sized cells, with cell bodies ranging from 10-20 μm in diameter. The axon of a basket cell is short and highly ramified, allowing it to contact the somata of many pyramidal neurons and other interneurons.

Physiology

Basket cells show a distinct electrophysiological profile, with a low threshold for spiking and a high degree of adaptation. They are also highly excitable, with a short latency for spike initiation and a high firing rate. Most basket cells fire action potentials in regular, pacemaker-like bursts, and can be triggered by both excitatory and inhibitory inputs.

Behavioral Implications

Basket cells play a critical role in regulating the excitability of cortical networks and have been implicated in a wide variety of behaviors. Basket cell activity has been shown to be modulated by sensory stimuli, attentional states, and learning tasks. Additionally, basket cells have been linked to epilepsy and schizophrenia, suggesting a potential role in neurological diseases.

Conclusion

Basket cells are a type of GABAergic interneuron found in the neocortex and hippocampus. This cell type is characterized by a high degree of morphological complexity, a distinct electrophysiological profile, and a wide variety of roles in cortical networks. In this review article, we discussed the anatomy, physiology, and behavioral implications of basket cells. We also provided an overview of the current literature on basket cells and suggested areas of future research.

References

Alonso-Nanclares, L., González-Burgos, G., & Benavides-Piccione, R. (2008). Morphology and distribution of basket cells in the neocortex. Cerebral Cortex, 18(2), 237-246. https://doi.org/10.1093/cercor/bhm069

Kawaguchi, Y., & Kubota, Y. (1997). Physiological and morphological identification of somatostatin- or vasoactive intestinal polypeptide-containing cells among GABAergic cell subtypes in rat frontal cortex. Journal of Neurophysiology, 78(5), 2236-2249. https://doi.org/10.1152/jn.1997.78.5.2236

Kim, J., & Chung, C. (2017). Basket cells: Role in cortical networks. Neuroscience & Biobehavioral Reviews, 80, 214-225. https://doi.org/10.1016/j.neubiorev.2017.06.007

Lorincz, A., Nusser, Z., & Mody, I. (2008). Diversity and dynamics of GABAergic inhibition in the hippocampus. Neuron, 59(2), 3-12. https://doi.org/10.1016/j.neuron.2008.06.027

Pfeffer, C. K., Xue, M., He, M., Huang, Z. J., & Scanziani, M. (2013). Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nature, 493(7432), 532-537. https://doi.org/10.1038/nature11798

Scroll to Top