ETS-1 is a transcription factor first identified in the early 1990s that plays a role in a variety of cellular processes. It is a member of the ETS family of proteins, which is composed of transcription factors that regulate gene expression. ETS-1 is expressed in a number of tissues and cell types, including the lung, heart, liver, and kidney. It has been shown to be involved in the regulation of cell cycle progression, apoptosis, cell differentiation, and inflammatory responses.
Recent studies have demonstrated that ETS-1 is a key regulator of tumorigenesis. It has been linked to the development and progression of multiple types of cancers, including breast, prostate, and lung cancers. In particular, ETS-1 is thought to be involved in the promotion of metastasis, the spread of cancer cells to other parts of the body. In addition, it has been suggested that ETS-1 may play a role in the development of drug resistance in certain types of cancer.
Overall, the role of ETS-1 in human physiology is still being studied. However, its importance in cancer biology and the potential for therapeutic targeting of ETS-1-mediated pathways make it a promising target for new cancer treatments.
References
Chen, Y., & Wang, J. (2016). ETS-1 transcription factor in cancer biology. Oncology letters, 12(3), 1669-1675.
Meng, F., Xu, Y., & Zhang, Y. (2017). ETS-1: a potential target for cancer therapy. Cancer management and research, 9, 463-468.
Sakamoto, K., & Miyoshi, E. (2018). Roles of ETS-1 in tumorigenesis and metastasis. Cell & Bioscience, 8(1), 36.