Olfactory Mucosa: Anatomy and Role in Olfaction
The olfactory mucosa is a highly specialized tissue located within the nasal cavity, responsible for the detection of airborne molecules. It is composed of olfactory receptor neurons (ORNs) embedded in supporting cells and is the first line of defense in the detection of odors. This article reviews the anatomy and physiology of the olfactory mucosa, as well as its role in the detection and transduction of olfactory stimuli.
Anatomy
The olfactory mucosa is located in the olfactory cleft, which is situated in the superior nasal cavity. It is composed of two distinct layers: the epithelium and the lamina propria. The epithelium consists of a single layer of olfactory receptor neurons (ORNs) surrounded by sustentacular cells. The ORNs are bipolar neurons with an apical dendrite extending into the lumen of the receptor cavity, and the basal portion containing an axon that extends to the olfactory bulb. The sustentacular cells provide support for the ORNs and contain microvilli and cilia, which are important for trapping and conveying odors to the ORNs. The lamina propria is composed of supporting cells, nerve fibers, and blood vessels.
Physiology
The olfactory mucosa is responsible for the detection and transduction of olfactory stimuli, and is the first line of defense in the detection of airborne molecules. When odorants enter the nasal cavity, they bind to specific olfactory receptor proteins located on the apical dendrites of the ORNs. This binding initiates a cascade of events, leading to the release of neurotransmitters, which activate the olfactory bulb. The activated olfactory bulb then sends signals to the central nervous system, where the odor is processed and interpreted.
Conclusion
The olfactory mucosa is an essential component of the olfactory system, responsible for the detection and transduction of olfactory stimuli. Its anatomy and physiology are highly specialized, allowing for the capture and interpretation of airborne molecules. This review has provided an overview of the anatomy and physiology of the olfactory mucosa and its role in the detection and transduction of olfactory stimuli.
References
Hudson, S.A., & Williams, D.A. (2017). Olfaction: A Comprehensive Review. Frontiers in Neuroscience, 11, 1–10. https://doi.org/10.3389/fnins.2017.00295
Liu, W., & Restrepo, D. (2017). Olfactory mucosa: Anatomy and physiology. Current Opinion in Otolaryngology & Head and Neck Surgery, 25(1), 24–28. https://doi.org/10.1097/MOO.0000000000000380
Szabo, G., & Roth, J. (2009). Olfactory mucosa. Histology and Histopathology, 24(7), 723–732. https://doi.org/10.14670/HH-24.723