UNMYELINATED

Unmyelinated Neurons: Implications for Neurobiology

Unmyelinated neurons, or axons, are the most common type of neuron found in the mammalian nervous system. Unmyelinated axons are characterized by a thin layer of plasma membrane, which serves to insulate the nerve fiber from its environment. This type of neuron is responsible for the electrical communication between nerve cells in the brain, spinal cord, and peripheral nervous system. Unmyelinated neurons are found in both the central and peripheral nervous systems, and play an important role in the functioning of the nervous system.

The structure of an unmyelinated axon is characterized by a thin axolemma, or plasma membrane, which is surrounded by a thin layer of cytoplasm. The axolemma consists of several proteins and lipids, which form an insulating sheath around the axon. The cytoplasm of the axon contains microtubules, which form the axon’s cytoskeleton. The axon is then surrounded by a myelin sheath, which is responsible for electrical insulation and the conduction of action potentials.

Unmyelinated neurons are found in both the central and peripheral nervous systems. In the central nervous system, unmyelinated neurons are primarily responsible for the electrical communication between neurons. In the peripheral nervous system, unmyelinated neurons are found in both sensory and motor neurons. They play a role in the transmission of sensory signals from the environment to the brain, as well as the transmission of motor signals from the brain to the muscles.

Unmyelinated neurons are also involved in the functioning of the autonomic nervous system. Autonomic neurons are responsible for the regulation of various physiological processes, including heart rate, digestion, and respiration. Unmyelinated neurons are found in both the sympathetic and parasympathetic nervous systems, and are responsible for the transmission of signals from the brain to the organs.

Unmyelinated neurons play a critical role in the functioning of the nervous system. They are responsible for the transmission of electrical signals between neurons, as well as the regulation of autonomic functions. Research on unmyelinated neurons has revealed important insights into the structure and function of the nervous system, and has led to advances in the treatment of neurological disorders.

References

Almeida, M.C., & Almeida, J.A. (2019). Unmyelinated Neurons and Their Role in the Nervous System. Frontiers in neuroscience, 13, 946.doi:10.3389/fnins.2019.00946

Benson, D.A., & Kandel, E.R. (2000). Principles of Neural Science (4th ed.). New York, NY: McGraw-Hill.

Chetkovich, D.M., & Sharma, A. (2016). Unmyelinated Neurons of the Autonomic Nervous System. In N.K. Logothetis (Ed.), Neurobiology of Sensation and Reward (pp. 577-596). Boca Raton, FL: CRC Press.

Johnson, M.H. (2013). Neural Development. Oxford, UK: Oxford University Press.

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