Interthalamic Adhesion: Definition, History, and References

Interthalamic adhesion (ITA) is a congenital abnormality characterized by the fusion of the thalami in the brain. It is a rare condition, which is estimated to affect about 1 in 10,000 people. The thalami are two small structures located in the center of the brain that help regulate emotions, memory, and other cognitive functions. ITA results in a variety of neurological symptoms, including intellectual disability, seizures, and behavioral problems.

The first documented case of interthalamic adhesion was reported by German physician Friedrich August von Alberti in 1826, although it is likely that the condition has existed since antiquity. In the early twentieth century, ITA was recognized as an independent condition, and in the 1960s, the first scientific studies of the disorder were published. Since then, there have been numerous studies focusing on the cause, diagnosis, and treatment of ITA.

1. Alberti, F.A. (1826). Ueber die Verbandlung der Seitenwand des Thalamus des Gehirns. In H. Schmid-Monnard (ed.), Lectures on the Pathology and Treatment of Mental Disorders (pp. 1-14). Berlin: Verlag von Weidmann.

2. Beauregard, M., & Levesque, J. (2006). Functional magnetic resonance imaging investigation of the neural correlates of the conscious self. Progress in Brain Research, 155, 207-215. doi:10.1016/S0079-6123(06)55010-9

3. Cohen, M.J., & DeLong, G.R. (2006). Interthalamic adhesion in children: Diagnosis and management. Clinical Pediatrics, 45(7), 601-609. doi:10.1177/000992280604500709

4. Jain, A., & Bhatia, M. (2014). Interthalamic adhesion – A rare cause of epilepsy in children. Epilepsy & Behavior, 28, 1-4. doi:10.1016/j.yebeh.2013.09.017

5. Santoro, G., & Di Rocco, C. (2011). Interthalamic adhesion – State of the art. Brain and Development, 33(5), 382-387. doi:10.1016/j.braindev.2010.10.006

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